SUMOylation of Neuronal K+ Channels: A Potential Therapeutic Pathway for Epilepsy and SUDEP?
نویسندگان
چکیده
Critical unmet clinical needs are the treatment of epilepsy without side effects and prevention of sudden unexpected death in epilepsy, or SUDEP. In this issue of Neuron, Qi et al. (2014), define how hyper-SUMOylation impacts K(+) channel activity in vivo and could serve as a potential pathway for development of novel epilepsy therapeutics.
منابع مشابه
Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death
Sudden unexplained death in epilepsy (SUDEP) is the most common cause of premature mortality in epilepsy and was linked to mutations in ion channels; however, genes within the channel protein interactome might also represent pathogenic candidates. Here we show that mice with partial deficiency of Sentrin/SUMO-specific protease 2 (SENP2) develop spontaneous seizures and sudden death. SENP2 is hi...
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عنوان ژورنال:
- Neuron
دوره 83 شماره
صفحات -
تاریخ انتشار 2014